Open the file "effect.txt" and change the resolution values in the first line according to your monitor resolution
EX:
My monitor resolution is 1440x900 so it need to be like this:
float4 ScreenSize=float4(1440,(1/900),(1440/900),(900/1440));
It should fix this problem, otherwise you will need desativate the Depht Of Field, open the file "enbseries_mastereffect.ini" and
in the second line "#define GPDOF" and change the "1" to "0"